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Article

Increased Hydrolysis of Oximino-β-Lactams by CMY-107, a Tyr199Cys Mutant Form of CMY-2 Produced by Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Kotsakis S D, Miriagou V, Vetouli E E, Bozavoutoglou E, Lebessi E, Tzelepi E, Tzouvelekis L S

Abstract excerpt

The cephalosporinase CMY-107, a Tyr199Cys mutant form of CMY-2 encoded by an IncI self-transferable plasmid carried by an Escherichia coli clinical strain, was characterized. The enzyme hydrolyzed oximino-cephalosporins and aztreonam more efficiently than CMY-2 did.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26438499
DOI: 10.1128/AAC.01793-15
PMCID: PMC4649145

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