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Article

Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target.

International journal of molecular sciences - 30 Sept 2015

Meng Jianzhou, Yang Yanhui, Xiao Chunling, Guan Yan, Hao Xueqin, Deng Qi, Lu Zhongyang

Abstract excerpt

Aspartic acid semialdehyde dehydrogenase (ASADH) lies at the first branch point in the essential aspartic acid biosynthetic pathway that is found in bacteria and plants but is absent from animals. Mutations in the asadh gene encoding ASADH produce an inactive enzyme, which is lethal. Therefore, in this study, we investigated the hypothesis that ASADH represents a new anti-Mycobacterium tuberculosis (MTB) target....

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Identifiers

PMID: 26437401
DOI: 10.3390/ijms161023572
PMCID: PMC4632714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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