Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.

Oncotarget - 20 Oct 2015

Wangpu Xiongzhi, Yang Xiao, Zhao Jingkun, Lu Jiaoyang, Guan Shaopei, Lu Jun, Kovacevic Zaklina, Liu Wensheng, Mi Lan, Jin Runsen, Sun Jing, Yue Fei, Ma Junjun, Lu Aiguo, Richardson Des R, Wang Lishun, Zheng Minhua

Abstract excerpt

N-myc downstream-regulated gene 1 (NDRG1), has been identified as an important metastasis suppressor for colorectal cancer (CRC). In this study, we investigated: (1) the effects of NDRG1 on CRC stemness and tumorigenesis; (2) the molecular mechanisms involved; and (3) the relationship between NDRG1 expression and colorectal cancer prognosis. Our investigation demonstrated that CRC cells with silenced NDRG1 showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AC133 Antigen
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HCT116 Cells

Share to HT29 Cells

Share to Hyaluronan Receptors

Share to Lymphatic Metastasis

Share to Neoplasm Transplantation

Share to Neoplastic Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 26418878
DOI: 10.18632/oncotarget.5294
PMCID: PMC4741810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.PMID 26418878Read ↗

Multifaceted and Intricate Oncogenic Mechanisms of NDRG1 in Head and Neck Cancer Depend on Its C-Terminal 3R-MotifSemantic proximity Read ↗

NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancerSemantic proximity Read ↗

NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patientsSemantic proximity Read ↗

NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patientsSemantic proximity Read ↗

N-myc Downstream Regulated Gene 1 (NDRG1) Promotes Metastasis of Human Scirrhous Gastric Cancer Cells through Epithelial Mesenchymal TransitionSemantic proximity Read ↗

Mechanism of N-Myc Downstream Regulated Gene-1 regulating Integrin expression to inhibit gastric cancer metastasisSemantic proximity Read ↗

The metastasis suppressor, Ndrg-1: a new ally in the fight against cancerSemantic proximity Read ↗

Upregulation of NDRG1 predicts poor outcome and facilitates disease progression by influencing the EMT process in bladder cancerSemantic proximity Read ↗

N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21Semantic proximity Read ↗

NDRG1 in Cancer: A Suppressor, Promoter, or Both?Semantic proximity Read ↗

The Function of N-Myc Downstream-Regulated Gene 2 (NDRG2) as a Negative Regulator in Tumor Cell MetastasisSemantic proximity Read ↗

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.