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Article

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

Oncotarget - 13 Oct 2015

Alves Sara, Castro Lisandra, Fernandes Maria Sofia, Francisco Rita, Castro Paula, Priault Muriel, Chaves Susana Rodrigues, Moyer Mary Pat, Oliveira Carla, Seruca Raquel, Côrte-Real Manuela, Sousa Maria João, Preto Ana

Abstract excerpt

The recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly frequent in colorectal cancer (CRC), we questioned whether/how mutant KRAS alleles regulate autophagy in CRC and its...

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Source

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Identifiers

PMID: 26418750
DOI: 10.18632/oncotarget.5021
PMCID: PMC4741568

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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