Article
Understanding the cancer cell phenotype beyond the limitations of current omics analyses.
The FEBS journal - 1 Jan 2016
Moreno-Sánchez Rafael, Saavedra Emma, Gallardo-Pérez Juan Carlos, Rumjanek Franklin D, Rodríguez-Enríquez Sara
Abstract excerpt
Efforts to understand the mechanistic principles driving cancer metabolism and proliferation have been lately governed by genomic, transcriptomic and proteomic studies. This paper analyzes the caveats of these approaches. As molecular biology's central dogma proposes a unidirectional flux of information from genes to mRNA to proteins, it has frequently been assumed that monitoring the changes in the gene...
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