Functional heterogeneity as reflected by topological parameters in a classical protein molecular model: t4 phage lysozyme.

Abstract excerpt

A systematic comparison with the Wild-Type (WT) of one-point mutants of bacteriophage T4 lysozyme was carried out using as difference markers the topological parameters of the protein contact networks corresponding to each crystallographic structure. The investigation concerned changes at the resolution level of single residue along the protein sequence. The results were correlated with (reported) changes in...

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