Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis.

doi:10.1038/srep14517

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Pharmacogenetics of Complement Factor H Y402H Polymorphism and Treatment of Neovascular AMD with Anti-VEGF Agents: A Meta-Analysis.

Scientific reports - 28 Sept 2015

Chen Guohai, Tzekov Radouil, Li Wensheng, Jiang Fangzheng, Mao Sihong, Tong Yuhua

Abstract excerpt

The purpose of this study is to investigate whether the Y402H polymorphism (rs1061170, a T-to-C transition at amino acid position 402) in the complement factor H (CFH) gene have a pharmacogenetics effect on the anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD). We performed a meta-analysis using databases including PubMed and EMBASE to find relevant...

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PMID: 26411831
DOI: 10.1038/srep14517
PMCID: PMC4585967

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