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Article

Disruption of murineAdamtsl4results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation

24 Sept 2015

Abstract excerpt

Human gene mutations have revealed that a significant number of ADAMTS (a disintegrin-like and metalloproteinase (reprolysin type) with thrombospondin type 1 motifs) proteins are necessary for normal ocular development and eye function. Mutations in human ADAMTSL4, encoding an ADAMTS-like protein which has been implicated in fibrillin microfibril biogenesis, cause ectopia lentis (EL) and EL et pupillae. Here, we...

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PMID: 26405179
DOI: 10.1093/hmg/ddv399

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Disruption of murineAdamtsl4results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiationPMID 26405179Read ↗

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