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Regulation and function of mitophagy in development and cancer

3 Nov 2013

Abstract excerpt

Beyond its role in recycling intracellular components nonselectively to sustain survival in response to metabolic stresses, autophagy can also selectively degrade specific cargoes such as damaged or dysfunctional organelles to maintain cellular homeostasis. Mitochondria, known as the power plant of cells, are the critical and dynamic organelles playing a fundamental role in cellular metabolism. Mitophagy, the...

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PMID: 24091872
DOI: 10.4161/auto.26550

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