Article
IL-1B rs1143623 and EEF1A1P11-RPL7P9 rs10783050 polymorphisms affect the glucose-lowing efficacy of metformin in Chinese overweight or obese Type 2 diabetes mellitus patients.
Pharmacogenomics - 1 Jan 2015
Xiao Di, Zhang Si-Min, Li Xi, Yin Ji-Ye, Gong Wei-Jing, Zheng Yi, Xu Xiao-Jing, Lin Xu, Ji Li-Nong, Liu Rang-Ru, Tang Qiang, Zhang Wei, Zhou Hong-Hao, Han Xue-Yao, Liu Zhao-Qian
Abstract excerpt
AIM: To investigate the potential genetic effect on metformin efficacy in overweight or obese Chinese Type 2 diabetes mellitus (T2DM) patients. PATIENTS & METHODS: 768 SNPs in or close to 207 genes were genotyped in 84 patients treated with metformin + glibenclamide/Xiaoke Pill. Significant SNPs were then verified in 107 recent-onset overweight or obese T2DM patients treated with metformin alone. Genotyping was...
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