Article
Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels.
The Journal of allergy and clinical immunology - 1 Jun 2016
Joseph Kusumam, Tholanikunnel Baby G, Wolf Bethany, Bork Konrad, Kaplan Allen P
Abstract excerpt
BACKGROUND: Hereditary angioedema with normal C1 inhibitor levels (HAE-N) is associated with a Factor XII mutation in 30% of subjects; however, the role of this mutation in the pathogenesis of angioedema is unclear. OBJECTIVE: We sought evidence of abnormalities in the pathways of bradykinin formation and bradykinin degradation in the plasma of patients with HAE-N both with and without the mutation. METHODS:...
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