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Identification of a Novel Small Molecule Inhibitor Against SARS Coronavirus Helicase

28 Dec 2015

Abstract excerpt

A new chemical inhibitor against severe acute respiratory syndrome (SARS) coronavirus helicase, 7-ethyl-8-mercapto-3-methyl-3,7-dihydro-1H-purine-2,6-dione, was identified. We investigated the inhibitory effect of the compound by conducting colorimetry-based ATP hydrolysis assay and fluorescence resonance energy transfer-based double-stranded DNA unwinding assay. The compound suppressed both ATP hydrolysis and...

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PMID: 26387819
DOI: 10.4014/jmb.1507.07078

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