Article
High definition viral vaccine strain identity and stability testing using full-genome population data--The next generation of vaccine quality control.
Vaccine - 26 Oct 2015
Höper Dirk, Freuling Conrad M, Müller Thomas, Hanke Dennis, von Messling Veronika, Duchow Karin, Beer Martin, Mettenleiter Thomas C
Abstract excerpt
BACKGROUND: Vaccines are the most effective prophylactic public health tools. With the help of vaccines, prevention of infectious disease spread and, in concert with other measures, even eradication has become possible. Until now, licensing and quality control require the determination of consensus genome sequences of replication competent infectious agents contained in vaccines. Recent improvements in sequencing...
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