Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.

doi:10.1534/genetics.115.181289

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Article

Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase.

Genetics - 1 Nov 2015

Hudson Andrew M, Mannix Katelynn M, Cooley Lynn

Abstract excerpt

The Drosophila Kelch protein is required to organize the ovarian ring canal cytoskeleton. Kelch binds and cross-links F-actin in vitro, and it also functions with Cullin 3 (Cul3) as a component of a ubiquitin E3 ligase. How these two activities contribute to cytoskeletal remodeling in vivo is not known. We used targeted mutagenesis to investigate the mechanism of Kelch function. We tested a model in which...

Topics

Actins
Animals
Cullin Proteins
Cytoskeleton
Drosophila
Drosophila Proteins
Female
Genitalia, Female
Microfilament Proteins
Mutagenesis
Phenotype
Proteasome Endopeptidase Complex
Ubiquitin-Protein Ligases

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Identifiers

PMID: 26384358
DOI: 10.1534/genetics.115.181289
PMCID: PMC4649639

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