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Article

RTB Lectin: a novel receptor-independent delivery system for lysosomal enzyme replacement therapies.

Scientific reports - 18 Sept 2015

Acosta Walter, Ayala Jorge, Dolan Maureen C, Cramer Carole L

Abstract excerpt

Enzyme replacement therapies have revolutionized patient treatment for multiple rare lysosomal storage diseases but show limited effectiveness for addressing pathologies in "hard-to-treat" organs and tissues including brain and bone. Here we investigate the plant lectin RTB as a novel carrier for human lysosomal enzymes. RTB enters mammalian cells by multiple mechanisms including both adsorptive-mediated and...

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Identifiers

PMID: 26382970
DOI: 10.1038/srep14144
PMCID: PMC4585660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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