Article
Potential mechanisms of attenuation for rifampicin-passaged strains of Flavobacterium psychrophilum.
BMC microbiology - 16 Sept 2015
Gliniewicz Karol, Wildung Mark, Orfe Lisa H, Wiens Gregory D, Cain Kenneth D, Lahmers Kevin K, Snekvik Kevin R, Call Douglas R
Abstract excerpt
BACKGROUND: Flavobacterium psychrophilum is the etiologic agent of bacterial coldwater disease in salmonids. Earlier research showed that a rifampicin-passaged strain of F. psychrophilum (CSF 259-93B.17) caused no disease in rainbow trout (Oncorhynchus mykiss, Walbaum) while inducing a protective immune response against challenge with the virulent CSF 259-93 strain. We hypothesized that rifampicin passage leads...
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