Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quinidine in the treatment of KCNT1-positive epilepsies.

Annals of neurology - 1 Dec 2015

Mikati Mohamad A, Jiang Yong-Hui, Carboni Michael, Shashi Vandana, Petrovski Slave, Spillmann Rebecca, Milligan Carol J, Li Melody, Grefe Annette, McConkie Allyn, Berkovic Samuel, Scheffer Ingrid, Mullen Saul, Bonner Melanie, Petrou Steven, Goldstein David

Abstract excerpt

We report 2 patients with drug-resistant epilepsy caused by KCNT1 mutations who were treated with quinidine. Both mutations manifested gain of function in vitro, showing increased current that was reduced by quinidine. One, who had epilepsy of infancy with migrating focal seizures, had 80% reduction in seizure frequency as recorded in seizure diaries, and partially validated by objective seizure evaluation on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Quinidine
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Drug Resistant Epilepsy

Share to Enzyme Inhibitors

Share to Nerve Tissue Proteins

Share to Potassium Channels

Share to Potassium Channels, Sodium-Activated

Source

Open in PubMed Open full text

Identifiers

PMID: 26369628
DOI: 10.1002/ana.24520
PMCID: PMC4811613

Genes

KCNT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quinidine in the treatment of KCNT1-positive epilepsies.PMID 26369628Read ↗

KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.Semantic proximity Read ↗

Early Treatment with Quinidine in 2 Patients with Epilepsy of Infancy with Migrating Focal Seizures (EIMFS) Due to Gain-of-Function KCNT1 Mutations: Functional Studies, Clinical Responses, and Critical Issues for Personalized Therapy.Semantic proximity Read ↗

Lack of response to quinidine in KCNT1-related neonatal epilepsy.Semantic proximity Read ↗

KCNT1-positive epilepsy of infancy with migrating focal seizures successfully treated with nonnarcotic antitussive drugs after treatment failure with quinidine: A case report.Semantic proximity Read ↗

Precision therapy with quinidine of KCNT1-related epileptic disorders: A systematic review.Semantic proximity Read ↗

Quinidine therapy for West syndrome with KCNTI mutation: A case report.Semantic proximity Read ↗

New use for an old drug: quinidine in KCNT1-related epilepsy therapy.Semantic proximity Read ↗

Quinidine Therapy for Lennox-Gastaut Syndrome With KCNT1 Mutation. A Case Report and Literature ReviewSemantic proximity Read ↗

A quinidine non responsive novel KCNT1 mutation in an Indian infant with epilepsy of infancy with migrating focal seizures.Semantic proximity Read ↗

Infantile refractory seizures due to de novo KCNT 1 mutation.Semantic proximity Read ↗

De novo gain-of-function variants in KCNT2 as a novel cause of developmental and epileptic encephalopathy.Semantic proximity Read ↗

Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic VariantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.