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Article

Lack of response to quinidine in KCNT1-related neonatal epilepsy.

Epilepsia - 1 Oct 2018

Numis Adam L, Nair Umesh, Datta Anita N, Sands Tristan T, Oldham Michael S, Patel Akash, Li Melody, Gazina Elena, Petrou Steven, Cilio Maria Roberta

Abstract excerpt

OBJECTIVE: To evaluate the clinical efficacy and safety of quinidine in patients with KCNT1-related epilepsy of infancy with migrating focal seizures (EIMFS) in the infantile period and to compare with the effect of quinidine on mutant channels in vitro. METHODS: We identified 4 patients with EIMFS with onset in the neonatal period, pathogenic variants in the KCNT1 gene, and lack of response to AEDs. Patients...

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Identifiers

PMID: 30182418
DOI: 10.1111/epi.14551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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