Article
Alcohol Consumption and Cardiovascular Disease: A Mendelian Randomization Study.
Circulation. Genomic and precision medicine - 1 Jun 2020
Larsson Susanna C, Burgess Stephen, Mason Amy M, Michaëlsson Karl
Abstract excerpt
BACKGROUND: The causal role of alcohol consumption for cardiovascular disease remains unclear. We used Mendelian randomization (MR) to predict the effect of alcohol consumption on 8 cardiovascular diseases. METHODS: Up to 94 single-nucleotide polymorphisms were used as instrumental variables for alcohol consumption. Genetic association estimates for cardiovascular diseases were obtained from large-scale consortia...
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