Article
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease.
Neurology - 13 Oct 2015
Wang Lisa, Aasly Jan O, Annesi Grazia, Bardien Soraya, Bozi Maria, Brice Alexis, Carr Jonathan, Chung Sun J, Clarke Carl, Crosiers David, Deutschländer Angela, Eckstein Gertrud, Farrer Matthew J, Goldwurm Stefano, Garraux Gaetan, Hadjigeorgiou Georgios M, Hicks Andrew A, Hattori Nobutaka, Klein Christine, Jeon Beom, Kim Yun J, Lesage Suzanne, Lin Juei-Jueng, Lynch Timothy, Lichtner Peter, Lang Anthony E, Mok Vincent, Jasinska-Myga Barbara, Mellick George D, Morrison Karen E, Opala Grzegorz, Pihlstrøm Lasse, Pramstaller Peter P, Park Sung S, Quattrone Aldo, Rogaeva Ekaterina, Ross Owen A, Stefanis Leonidas, Stockton Joanne D, Silburn Peter A, Theuns Jessie, Tan Eng K, Tomiyama Hiroyuki, Toft Mathias, Van Broeckhoven Christine, Uitti Ryan J, Wirdefeldt Karin, Wszolek Zbigniew, Xiromerisiou Georgia, Yueh Kuo-Chu, Zhao Yi, Gasser Thomas, Maraganore Demetrius M, Krüger Rejko, Sharma Manu
Abstract excerpt
OBJECTIVES: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). METHODS: We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, SCA3, SCA6, and...
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