Article
The possible involvement of mitochondrial dysfunctions in Lewy body dementia: a systematic review.
Functional neurology - 1 Jan 2000
Spano Mariangela, Signorelli Maria, Vitaliani Roberta, Aguglia Eugenio, Giometto Bruno
Abstract excerpt
The hallmark of dementia with Lewy bodies (DLB) is the “Lewy body”, an abnormal aggregation of alpha-synuclein found in some areas of the brain. The brain is the organ/system that is most vulnerable to this oxidative damage, and reactive oxygen species can cause neurodegenerative diseases. Different models of mitochondrial deregulation have been compared in DLB. The results are consistent with the hypothesis that...
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