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Article

ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment.

Clinical journal of the American Society of Nephrology : CJASN - 6 Nov 2015

Rurali Erica, Banterla Federica, Donadelli Roberta, Bresin Elena, Galbusera Miriam, Gastoldi Sara, Peyvandi Flora, Underwood Mary, Remuzzi Giuseppe, Noris Marina

Abstract excerpt

BACKGROUND AND OBJECTIVES: Acute renal impairment is observed in 11%-23% of patients with congenital thrombotic thrombocytopenic purpura (TTP) and deficiency of a disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13, a metalloprotease that cleaves von Willebrand factor [VWF] multimers), a substantial percentage of whom develop CKD during follow-up. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26342041
DOI: 10.2215/CJN.01700215
PMCID: PMC4633781

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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