Article
The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma.
Oncotarget - 6 Oct 2015
Döppler Heike, Bastea Ligia, Borges Sahra, Geiger Xochiquetzal, Storz Peter
Abstract excerpt
Vasodilator-stimulated phosphoprotein (VASP) signaling is critical for dynamic actin reorganization processes that define the motile phenotype of cells. Here we show that VASP is generally highly expressed in normal breast tissue and breast cancer. We also show that the phosphorylation status of VASP at S322 can be predictive for breast cancer progression to an aggressive phenotype. Our data indicate that...
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