Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

doi:10.1016/j.neuron.2015.08.020

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Article

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Neuron - 2 Sept 2015

Zhao Yingjun, Tseng I-Chu, Heyser Charles J, Rockenstein Edward, Mante Michael, Adame Anthony, Zheng Qiuyang, Huang Timothy, Wang Xin, Arslan Pharhad E, Chakrabarty Paramita, Wu Chengbiao, Bu Guojun, Mobley William C, Zhang Yun-Wu, St George-Hyslop Peter, Masliah Eliezer, Fraser Paul, Xu Huaxi

Abstract excerpt

Progressive supranuclear palsy (PSP) is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown. An SNP (rs1768208 C/T) has been identified as a strong risk factor for PSP. Here, we identified a much higher T-allele occurrence and increased levels of the pro-apoptotic protein appoptosin in PSP patients. Elevations in appoptosin correlate with activated caspase-3 and...

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PMID: 26335643
DOI: 10.1016/j.neuron.2015.08.020
PMCID: PMC4575284

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