Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.

PloS one - 1 Jan 2015

Barratt Daniel T, Klepstad Pål, Dale Ola, Kaasa Stein, Somogyi Andrew A

Abstract excerpt

Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated generally in pain, opioid analgesia, cognitive dysfunction, and sickness type symptoms reported by cancer patients. We aimed to determine if genetic polymorphisms in neuroimmune activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Cutaneous
Share to Analgesics, Opioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognition Disorders

Share to Fentanyl

Share to Immunity, Innate

Share to Myeloid Differentiation Factor 88

Share to Pain Management

Source

Open in PubMed Open full text

Identifiers

PMID: 26332828
DOI: 10.1371/journal.pone.0137179
PMCID: PMC4557995

Genes

MYD88
ABCB1
ARRB2
BDNF
CASP1
COMT
CRP
OPRM1
STAT6
TGFB1
TLR2
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.PMID 26332828Read ↗

Pharmacokinetic and neuroimmune pharmacogenetic impacts on slow-release morphine cancer pain control and adverse effects.Semantic proximity Read ↗

Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain.Semantic proximity Read ↗

Innate Immune and Neuronal Genetic Markers Are Highly Predictive of Postoperative Pain and Morphine Patient-Controlled Analgesia Requirements in Indian but Not Chinese or Malay Hysterectomy Patients.Semantic proximity Read ↗

Genetic insights into associations of multisite chronic pain with common diseases and biomarkers using data from the UK Biobank.Semantic proximity Read ↗

Cancer Pain is Not One Size Fits All: Evolving from Tradition to PrecisionSemantic proximity Read ↗

Genome-wide enriched pathway analysis of acute post-radiotherapy pain in breast cancer patients: a prospective cohort studySemantic proximity Read ↗

Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.Semantic proximity Read ↗

A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.Semantic proximity Read ↗

Molecular epidemiology, cancer-related symptoms, and cytokines pathway.Semantic proximity Read ↗

Genomic Variants Associated With Cancer-Related Fatigue: A Systematic ReviewSemantic proximity Read ↗

Genetic variation and cognitive dysfunction in opioid-treated patients with cancer.Semantic proximity Read ↗

Genome-wide association study of nociceptive musculoskeletal pain treatment response in UK BiobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.