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Article

Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma.

Acta neuropathologica - 1 Oct 2015

Liu Qun, Liu Yuexin, Li Wenliang, Wang Xiaoguang, Sawaya Raymond, Lang Frederick F, Yung W K Alfred, Chen Kexin, Fuller Gregory N, Zhang Wei

Abstract excerpt

Ten to twenty percent of newly diagnosed glioblastoma (GBM) patients initially present with multiple lesions, termed multifocal or multicentric GBM (M-GBM). The prognosis of these patients is poorer than that of solitary GBM (S-GBM) patients. However, it is unknown whether multifocality has a genetic, epigenetic, or molecular basis. Here, we identified the genetic and epigenetic characteristics of M-GBM by...

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Identifiers

PMID: 26323991
DOI: 10.1007/s00401-015-1470-8
PMCID: PMC4776337

Genes

IDH1
ATRX
PDGFRA

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