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Article

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells

15 Jan 2019

Abstract excerpt

Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood diseases in the world. Persistent expression of the fetal ß-like globin, also known as 𝛾-globin, can ameliorate both disorders by serving in place of the adult ß-globin as a part of the fetal hemoglobin tetramer (HbF). Here we use CRISPR-Cas9 gene editing...

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PMID: 30645582
DOI: 10.1371/journal.pone.0208237

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