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Article

Overexpression of PDZ-binding kinase confers malignant phenotype in prostate cancer via the regulation of E2F1.

International journal of biological macromolecules - 1 Nov 2015

Chen Jia-Hong, Liang Yu-Xiang, He Hui-Chan, Chen Jin-Yan, Lu Jian-Ming, Chen Guo, Lin Zhuo-Yuan, Fu Xin, Ling Xiao-Hui, Han Zhao-Dong, Jiang Fu-Neng, Zhong Wei-De

Abstract excerpt

Roles and mechanisms of cell cycle-specific transcription factor E2F1 on prostate cancer (PCa) have not been fully elucidated. To address this problem, we here identified PDZ-binding kinase (PBK) as a direct target for E2F1 through bioinformatics binding site prediction, combined with chromatin i...

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Identifiers

PMID: 26314905
DOI: 10.1016/j.ijbiomac.2015.08.048

Genes

PBK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26314905-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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