Article
Sensitivity to chromosomal breakage as risk factor in young adults with oral squamous cell carcinoma.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Mar 2016
Braakhuis Boudewijn J M, Nieuwint Aggie W M, Oostra Anneke B, Joenje Hans, Flach Géke B, Graveland A Peggy, Brakenhoff Ruud H, Leemans C René
Abstract excerpt
OBJECTIVE: Oral squamous cell carcinoma (OSCC) may develop in young adults. In contrast to older patients, the well-known etiological factors, exposure to tobacco and alcohol, play a minor role in the carcinogenesis in this patient group. It has been suggested that an intrinsic susceptibility to environmental genotoxic exposures plays a role in the development of OSCC in these patients. The hypothesis was tested...
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