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Article

Association between apolipoprotein E epsilon4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C.

Psychosomatics - 1 Jan 2000

Gochee Peter A, Powell Elizabeth E, Purdie David M, Pandeya Nirmala, Kelemen Livia, Shorthouse Claudia, Jonsson Julie R, Kelly Brian

Abstract excerpt

Neuropsychiatric complications are common in patients with chronic hepatitis C undergoing treatment with interferon alpha. These side effects include alterations of mood, cognition, and neuroendocrine function and are unpredictable. In a number of neurological disorders characterized by neuropsychiatric symptoms and cognitive dysfunction, inheritance of an apolipoprotein E (APOE) epsilon4 allele is associated...

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Source

Identifiers

PMID: 14709760
DOI: 10.1176/appi.psy.45.1.49

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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