Article
Single Nucleotide Polymorphism Heritability of Behavior Problems in Childhood: Genome-Wide Complex Trait Analysis.
Journal of the American Academy of Child and Adolescent Psychiatry - 1 Sept 2015
Pappa Irene, Fedko Iryna O, Mileva-Seitz Viara R, Hottenga Jouke-Jan, Bakermans-Kranenburg Marian J, Bartels Meike, van Beijsterveldt Catharina E M, Jaddoe Vincent W V, Middeldorp Christel M, Rippe Ralph C A, Rivadeneira Fernando, Tiemeier Henning, Verhulst Frank C, van IJzendoorn Marinus H, Boomsma Dorret I
Abstract excerpt
OBJECTIVE: Genetic factors contribute to individual differences in behavior problems. In children, genome-wide association studies (GWAS) have yielded the first suggestive results when aiming to identify genetic variants that explain heritability, but the proportion of genetic variance that can be attributed to common single nucleotide polymorphisms (SNPs) remains to be determined, as only a few studies have...
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