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Quencher Group Induced High Specificity Detection of Telomerase in Clear and Bloody Urines by AIEgens

19 Aug 2015

Abstract excerpt

Telomerase is a widely used tumor biomarker for early cancer diagnosis. On the basis of the combined use of aggregation-induced emission (AIE) fluorogens and quencher, a quencher group induced high specificity strategy for detection of telomerase activity from cell extracts and cancer patients' urine specimens was creatively developed. In the absence of telomerase, fluorescence background is extremely low due to...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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PMID: 26287560
DOI: 10.1021/acs.analchem.5b02699

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