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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres

27 Nov 2022

Abstract excerpt

Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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PMID: 36437244
DOI: 10.1038/s41419-022-05443-y

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