Article
CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA.
Molecular cancer - 14 Aug 2015
Conigliaro Alice, Costa Viviana, Lo Dico Alessia, Saieva Laura, Buccheri Simona, Dieli Francesco, Manno Mauro, Raccosta Samuele, Mancone Carmine, Tripodi Marco, De Leo Giacomo, Alessandro Riccardo
Abstract excerpt
BACKGROUND: CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. METHODS: Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma...
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