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Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

13 Aug 2015

Abstract excerpt

Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, using intravital microscopy in mice. Our data suggest that sporozoites exhibit two types of...

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PMID: 26271010
DOI: 10.7554/elife.07789

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