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Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development

28 Jul 2015

Abstract excerpt

Abnormal joint morphogenesis is linked to clinical conditions such as Developmental Dysplasia of the Hip (DDH) and to osteoarthritis (OA). Muscle activity is known to be important during the developmental process of joint morphogenesis. However, less is known about how this mechanical stimulus affects the behaviour of joint cells to generate altered morphology. Using zebrafish, in which we can image all joint...

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PMID: 26253758
DOI: 10.1016/j.jbiomech.2015.07.017

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