Article
Prognostic role of genetic biomarkers in clinical progression of prostate cancer.
Experimental & molecular medicine - 7 Aug 2015
Alvarez-Cubero Maria Jesus, Martinez-Gonzalez Luis Javier, Saiz Maria, Carmona-Saez Pedro, Alvarez Juan Carlos, Pascual-Geler Manrique, Lorente Jose Antonio, Cozar Jose Manuel
Abstract excerpt
The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. A cohort of 451 men (235 patients and 216 controls) was studied. We calculated means of regression analysis using clinical values (stage, prostate-specific antigen,...
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