Article
The molecular landscape of premenopausal breast cancer.
Breast cancer research : BCR - 7 Aug 2015
Liao Serena, Hartmaier Ryan J, McGuire Kandace P, Puhalla Shannon L, Luthra Soumya, Chandran Uma R, Ma Tianzhou, Bhargava Rohit, Modugno Francesmary, Davidson Nancy E, Benz Steve, Lee Adrian V, Tseng George C, Oesterreich Steffi
Abstract excerpt
INTRODUCTION: Breast cancer in premenopausal women (preM) is frequently associated with worse prognosis compared to that in postmenopausal women (postM), and there is evidence that preM estrogen receptor-positive (ER+) tumors may respond poorly to endocrine therapy. There is, however, a paucity of studies characterizing molecular alterations in premenopausal tumors, a potential avenue for personalizing therapy...
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