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Article

Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data.

Briefings in bioinformatics - 1 Mar 2016

Zhang Pan, Samuels David C, Lehmann Brian, Stricker Thomas, Pietenpol Jennifer, Shyr Yu, Guo Yan

Abstract excerpt

The rapid progress in high-throughput sequencing has significantly enriched our capacity for studying the mitochondrial DNA (mtDNA). In addition to performing specific mitochondrial targeted sequencing, an increasingly popular alternative approach is using the off-target reads from exome sequencing to infer mtDNA variants, including single nucleotide polymorphisms (SNPs) and heteroplasmy. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26249222
DOI: 10.1093/bib/bbv057
PMCID: PMC5974936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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