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Article

Fluconazole and Voriconazole Resistance in Candida parapsilosis Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene.

Antimicrobial agents and chemotherapy - 1 Oct 2015

Branco Joana, Silva Ana P, Silva Raquel M, Silva-Dias Ana, Pina-Vaz Cidália, Butler Geraldine, Rodrigues Acácio G, Miranda Isabel M

Abstract excerpt

Candida parapsilosis is the second most prevalent fungal agent causing bloodstream infections. Nevertheless, there is little information about the molecular mechanisms underlying azole resistance in this species. Mutations (G1747A, A2619C, and A3191C) in the MRR1 transcription factor gene were identified in fluconazole- and voriconazole-resistant strains. Independent expression of MRR1 genes harboring these...

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Identifiers

PMID: 26248365
DOI: 10.1128/AAC.00842-15
PMCID: PMC4576118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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