Article
In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015
Smith Daniel R, Maestre-Reyna Manuel, Lee Gloria, Gerard Harry, Wang Andrew H-J, Watnick Paula I
Abstract excerpt
The estuarine gram-negative rod and human diarrheal pathogen Vibrio cholerae synthesizes a VPS exopolysaccharide-dependent biofilm matrix that allows it to form a 3D structure on surfaces. Proteins associated with the matrix include, RbmA, RbmC, and Bap1. RbmA, a protein whose crystallographic structure suggests two binding surfaces, associates with cells by means of a VPS-dependent mechanism and promotes biofilm...
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