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Article

A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Dalia Ankur B, Seed Kimberley D, Calderwood Stephen B, Camilli Andrew

Abstract excerpt

Natural transformation is one mechanism of horizontal gene transfer (HGT) in Vibrio cholerae, the causative agent of cholera. Recently, it was found that V. cholerae isolates from the Haiti outbreak were poorly transformed by this mechanism. Here, we show that an integrating conjugative element (ICE)-encoded DNase, which we name IdeA, is necessary and sufficient for inhibiting natural transformation of Haiti...

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Identifiers

PMID: 26240317
DOI: 10.1073/pnas.1509097112
PMCID: PMC4547284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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