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Article

Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration.

Regenerative medicine - 1 Jan 2015

Corenblum Mandi J, Flores Andrew J, Badowski Michael, Harris David T, Madhavan Lalitha

Abstract excerpt

AIM: Here we investigated the neuroprotective potential of systemic CD34(+) human cord blood cells (hCBCs) in a 6-hydroxydopamine rat model of Parkinson's disease. METHODS: Purified CD34(+) hCBCs were intravenously administered to rats subjected to 6-hydroxydopamine 24 h earlier, and behavioral and immunohistological analysis performed. RESULTS: CD34(+) hCBC administration significantly prevented host...

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Identifiers

PMID: 26237701
DOI: 10.2217/rme.15.32

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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