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Article

Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox.

Scientific reports - 3 Aug 2015

Liu Qiang, Fan Changfa, Zhou Shuya, Guo Yanan, Zuo Qin, Ma Jian, Liu Susu, Wu Xi, Peng Zexu, Fan Tao, Guo Chaoshe, Shen Yuelei, Huang Weijin, Li Baowen, He Zhengming, Wang Youchun

Abstract excerpt

Due to the increasing concern of using smallpox virus as biological weapons for terrorist attack, there is renewed interest in studying the pathogenesis of human smallpox and development of new therapies. Animal models are highly demanded for efficacy and safety examination of new vaccines and therapeutic drugs. Here, we demonstrated that both wild type and immunodeficient rats infected with an engineered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26235050
DOI: 10.1038/srep11397
PMCID: PMC4522659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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