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Article

Improved Multiplex Ligation-dependent Probe Amplification (i-MLPA) for rapid copy number variant (CNV) detection.

Clinica chimica acta; international journal of clinical chemistry - 23 Oct 2015

Saxena Sonal, Gowdhaman Kavitha, Kkani Poornima, Vennapusa Bhavyasri, Rama Subramanian Chellamuthu, Ganesh Kumar S, Mohan Kommu Naga

Abstract excerpt

BACKGROUND: In Multiplex Ligation-dependent Probe Amplification (MLPA), copy number variants (CNVs) for specific genes are identified after normalization of the amounts of PCR products from ligated reference probes hybridized to genomic regions that are ideally free from normal variation. However, we observed ambiguous calls for two reference probes in an investigation of the human 15q11.2 region by MLPA among 20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26234520
DOI: 10.1016/j.cca.2015.07.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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