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Article

Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice.

Journal of inherited metabolic disease - 1 Jan 2016

Gupta Sapna, Wang Liqun, Kruger Warren D

Abstract excerpt

Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy). Betaine supplementation, which can lower tHcy by stimulating homocysteine remethylation to methionine, is often given to CBS deficient patients in combination with other treatments such as methionine restriction and supplemental B-vitamins. However, the effectiveness of...

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Identifiers

PMID: 26231230
DOI: 10.1007/s10545-015-9883-z
PMCID: PMC4784539

Genes

CBS
BHMT
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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