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Article

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado–Joseph disease

27 Jul 2015

Abstract excerpt

Machado-Joseph disease (MJD) is a fatal, dominantly inherited neurodegenerative disorder associated with an expanded polyglutamine tract within the ataxin-3 protein, and characterized by progressive impairment of motor coordination, associated with neurodegeneration of specific brain regions, including cerebellum and striatum. The currently available therapies do not allow modification of disease progression....

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PMID: 26220979
DOI: 10.1093/hmg/ddv271

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