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Article

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

27 Jul 2015

Abstract excerpt

Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus...

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PMID: 26214839
DOI: 10.1371/journal.pbio.1002198

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