Article
Coenzyme Q10 Prevents Insulin Signaling Dysregulation and Inflammation Prior to Development of Insulin Resistance in Male Offspring of a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth.
Endocrinology - 1 Oct 2015
Tarry-Adkins Jane L, Fernandez-Twinn Denise S, Madsen Ralitsa, Chen Jian-Hua, Carpenter Asha, Hargreaves Iain P, McConnell Josie M, Ozanne Susan E
Abstract excerpt
Low birth weight and rapid postnatal growth increases the risk of developing insulin resistance and type 2 diabetes in later life. However, underlying mechanisms and potential intervention strategies are poorly defined. Here we demonstrate that male Wistar rats exposed to a low-protein diet in utero that had a low birth weight but then underwent postnatal catch-up growth (recuperated offspring) had reductions in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.