Early biomarkers identified in a rat model of a healthier phenotype based on early postnatal dietary intervention may predict the response to an obesogenic environment in adulthood.

Abstract excerpt

Moderate maternal calorie restriction during lactation in rats provides certain protection against obesity in adult offspring. Hence, we used this model with 20% calorie restriction to identify early changes at the gene expression level in key tissues involved in energy homeostasis, as well as to assess whether they are maintained in adulthood, to consider them as potential biomarkers of metabolic health....

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